Abstract: Paleo-temperature reconstruction is one of the most important components in paleoceanographical studies. The evolution of surface currents driven by paleo-temperature plays an important role in global climate change. In recent years, three newly geochemical proxies (Mg/Ca, Uk'37 and TEX₈₆) have been widely accepted despite some defects. In the Okinawa Trough, there are obvious discrepancies among the results using different paleo-temperature proxies and the mechanism is unknown. In this paper, we summarized the applicability, merits and faults of the above three paleo-temperature proxies from a global perspective, and analyzed their temporal and spatial differences of the results. Emphases are put on the research history and status in quo of Mg/Ca, Uk'37 and TEX₈₆ in the Okinawa Trough, the importance of regional applicability of these paleo-temperature proxies, and the future challenge of paleo-temperature evolution mechanism studies since the last deglaciation in the Okinawa Trough.